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A: Timeline varies: Biochemical response: 2-4 weeks (B12 and homocysteine normalize) Clinical response: 4-8 weeks (mood improvement) Maximal benefit: 8-12 weeks Some patients notice: Improved energy: 2-3 weeks Better mood: 4-6 weeks Full antidepressant response: 8-12 weeks Q: Should all patients on SSRIs/SNRIs take B12