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This can result in cardiopulmonary (heart and lung) complications (eg, high or low blood pressure, slow heart rate, irregular heartbeat, respiratory distress, shock), hematologic and renal (blood and kidney) systems (eg, excess ammonia in the blood, electrolyte disturbance, anemia, acute renal failure), and the central nervous system (eg, nausea/vomiting, confusion/restlessness, blindness, twitches/seizures, lethargy/paralysis, dilated/nonreactive pupils, coma), as well as death (Gravenstein 1997)
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An application of cyclophosphamide (180 mg/kg i.p.) induced significant disturbances