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Drug Combination in Polymeric Nanocarriers for Chemotherapy of Cancer: Preclinical Outcomes in the Last Ten Years

Chemotherapy-related toxicities were assessed after every cycle according to Common Toxicity Criteria of the National Cancer Institute (NCI-CTC, version 2.0) ( The chemotherapy regimen included: Adriamycin-Cyclophosphamide x4 followed by taxane x4 (docitaxel or paclitaxel): Doxorubicin 60mg/m 2 on day 1, cyclophosphamide 600mg on day 1, paclitaxel 175mg/m 2 on day 1 OR docitaxel 100mg/m 2 on day 1, repeated every 3 weeks

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remission) and anatomical compartments, a dynamic landscape that is difficult to capture with the predominantly cross-sectional nature of current research (146, 147)