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Neuron 79 , 54–68 (2013)

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62) showed that the initial step of autocatalytic processing of glycosylasparaginase, a member of Ntn hydrolases, is an N-O or N-S acyl shift at its residue 152 to yield an ester intermediate because the processing rate of the precursor, whose Thr-152 is replaced by Cys, was very much accelerated by the addition of NH 2 OH at pH 7